Tumor suppressor function of FOXO1 in diffuse large B-cell lymphomas: mechanisms of regulation and personalized rational targeting strategies.

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Associate prof. Przemysław Juszczyński, MD PhD.

He was born in Łódź, Poland. He graduated from Medical University of Lodz in 2000 with an MD degree. During third year of Medical School, he became involved in scientific activities of the Department of Hematology. After graduation he enrolled the PhD program in the same Department under the supervision of prof. Krzysztof Warzocha. In 2001 he trained at the Dept. of Hematology and Hematologic Malignancies Diagnostic Services, Leeds General Infirmary, Leeds, UK. In 2002 he defended his dissertation “Genetic polymorphisms in the tumor necrosis factor (TNF) locus influence non-Hodgkin's lymphoma outcome” and obtained PhD degree. His work was recognized and awarded by the START fellowship from Foundation for Polish Science. Right afterwards, he received ICRETT fellowship from International Union Against Cancer (Geneva, Switzerland) and KOLUMB fellowship from Foundation for Polish Science and in August 2003 began his postdoctoral training at the Dana Farber Cancer Institute, Harvard Medical School, Boston, MA in prof. Margaret Shipp laboratory. He completed multiple bioinformatic courses at the Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA. In 2006 he joined Harvard Medical School junior faculty as an Instructor in Medicine. In 2010, he joined the Institute of Hematology and Transfusion Medicine, where he obtained DSc (habilitation) degree and was appointed as associate professor. Since 2011 he is Scientific Director of the Institute. In the same year, he received a TEAM grant “Tumor suppressor function of FOXO1 in diffuse large B-cell lymphomas: mechanisms of regulation and personalized rational targeting strategies” from the Foundation for Polish Science. Przemyslaw is an active member of the American Association for Cancer Research and American Society of Hematology. In his spare time he enjoys traveling, photography and conversations with his daughters.



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Ewa Jabłońska, PhD 

Originally comes from Torun, Poland. From 1997 to 2001 she attended 4th High School in Torun. In 2006 she received B.S. and M.S. degrees in Biotechnology  from the Nicolaus Copernicus University in Torun, Poland. Afterwards, she moved to Giessen, Germany where she started her PhD studies  in the Institute of Biochemistry at the University of Giessen Lung  Center under the supervision of Prof. K.T. Preissner and Dr M. Wygrecka.  The subject of her dissertation was the role of coagulation Factor XII (FXII) in the pathogenesis of idiopathic pulmonary fibrosis (IPF). In 2006 she  started  ‘Molecular Biology and Medicine of the Lung’  graduate program and earned  Ph.D. degree at  Justus Liebig University  in Giessen  in 2010. During her PhD studies she received Young Investigator Award at XXII Congress of International Society on Thrombosis and Haemostasis and Rudolf-Marx Award at  54th Congress of German Society on Thrombosis and Haemostasis . After completing her PhD studies  Ewa moved back to Poland and started her postdoctoral training in prof. Juszczynski’s  lab. Her present research interests are microRNAs and their involvement in cancer biology, particularly in the development of lymphoma . In her spare time, she enjoys horse riding and bicycling.



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Przemysław Kiliszek, M.Sc. 

He was born on 14th April 1986 in Warsaw. From 2002 to 2005  he attended Staszic High School in Warsaw. Afterwards, he studied pharmacy at the Medical University of Warsaw. For his achievements, he was awarded a scientific scholarship. He has conducted Master’s thesis research at the Pharmacodynamics Research Unit and graduated with an overall result very good, and obtained a professional degree of Master in Pharmacy. The topic of his thesis was “Influence of Long-Term Paracetamol (Acetaminophen) Use on Spatial Memory Processes in Rats.”
During the studies, Przemysław Kiliszek was an active member of the International Pharmaceutical Students’ Federation and managed the global Student Exchange Program  as a member of the Student Exchange Committee. Apart from it, he practiced in the microbiological department of the IAREN Laboratories in Portugal and clinical trial departments of pharmaceutical companies. Since graduating the High School, he has been coaching pupils in mathematics, physics, chemistry and biology. Przemysław is particularly interested in molecular mechanisms of action of medicines, finding new therapeutic targets and approaches and a biostatistics. In 2011, he joined prof. Juszczynskis TEAM group at the Institute of Hematology and Transfusion Medicine. He likes motorcycles and extreme sports.



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Anna Polak, M.Sc.

She was born in Warsaw in 1984. From 1999 to 2003 she attended 43rd High School in Warsaw. Afterwards, she studied biology at the University of Life Sciences in Warsaw and was awarded a scientific scholarship. In 2008 she obtained M.Sc. degree in Biology with an overall result: very good. She performed her thesis work in the field of molecular virusology at the Department of Protein Biosynthesis of the Institute of Biochemistry and Biophysics, Polish Academy of Sciences. The topic of her thesis was “Cloning, mutagenesis and transient expression of Potato Leafroll Virus (PLRV) coat protein gene in tobacco protoplast“. She defended her thesis with academic committee honours. After obtaining Master’s degree she started to work as molecular biologist at the Department of Genetics of the Institute of Biochemistry and Biophysics, where she conducted research on the protein degradation processes (autophagy and ubiquitination) using yeast Saccharomyces cerevisiae as a model organism.
In 2011 she joined prof. Juszczynski’s lab. Her present research interest include identification of molecular mechanisms responsible for drug resistance in leukemic cells. In her spare time Anna enjoys travelling and outdoor activities.



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Weronika Prusisz, M.Sc.

She was born in 1985 in Lodz. From 2000 to 2005 she attended Copernicus High School in Lodz. Afterwards, she studied biotechnology at the Faculty of Biology and specialized in Molecular Biology. During the studies, Weronika was awarded scientific scholarship and Ministry Award and graduated with excellent result. The topic of her Master’s thesis was Cloning, expression and purification of TRAIL human recombinant protein. Apart from the University curriculum, she gained research experience through her internship in the laboratories of Rockefeller University (New York, USA) and the Institute of Medical Biology and Genome Institute in Singapore. In the middle of Weronika's scientific interests are molecular mechanisms leading to cancer and identification of rational therapeutic targets. Currently she enrolled a PhD programme at the Institute of Hematology and Transfusion Medicine within the framework of the TEAM grant supervised by prof. P. Juszczynski. Weronika works with microRNAs involved in modulation of lymphocyte signaling. In her free time Weronika bakes, dances and attends music festivals. She has two black cats called Trick and Treat and tries to grow carnivorous plants with miscellaneous results.



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Tomasz Sewastianik, M.Sc.

He was born in Białystok, Poland in 1987. From 2003 to 2006 he attended class with bio-chemical profile in K.K. Baczynski’s High School in Bialystok. In 2006 he began his studies of Biotechnology at the Department of Industrial Microbiology at Maria Curie-Skłodowska University in Lublin, which he completed in 2009 as a Bachelor of Science in Biotechnology based on his thesis on bioethanol production. In the same year he commenced Master Degree studies at the same university in the Department of Virology and Immunology, from which he graduated in 2011. His thesis was written at the Laboratory of Molecular Bases of Aging of Nencki Institute of Experimental Biology in Warsaw on the topic of the role of the DNA damage response pathway in cell death of human T cells. During the programmes he participated in the Bachelor’s specialisation internship, two Master’s specialisation internships at the mentioned institutions, where he was investigating cell death in response to chemotherapeutics. In addition, he trained at the  University of Tübingen Medical School in Germany in the Tübingen Aging and Tumour Immunology Group where he was improving his flow cytometry skills. In 2011 Tomasz enrolled in the Doctoral Programme at the Institute of Hematology and Transfusion Medicine in Warsaw, a TEAM Project under the supervision of Przemysław Juszczyński, where he is currently working on defining the role of acetylation and oxidative stress in modulating FOXO1 activity and assessing potential targeting strategies. In his free time Tomasz releases extra energy and bad emotions in training and meeting with his friends.



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Maciej Szydłowski, PhD.

He was born on March 5 1981 in Czeladź. He grew up in Lelów. From 1996 to 2000 he attended R. Traugutt High School in Czestochowa. Afterwards, he studied at the University of Silesia in Katowice (September 2000 - May 2005), where he obtained M.Sc. in Biology. He performed his diploma work (“Generation of the promoter deletion constructs of the human tumorous imaginal discs (htid) and neighbour of tid (hnot) genes”) in frame of the Erasmus/Socrates Scholarship at the Johannes Gutenberg University in Mainz (Germany), under supervision of Prof. Dr. Ursula Kurzik-Dumke. After completing his studies, he worked as a research assistant in the Department of Microbiology at the home university in Katowice (11.2005 – 09.2006). In September 2006, he was awarded a 3-year Deutscher Akademischer Austauschdienst (DAAD) Scholarship for PhD studies he performed at the University in Mainz, in the Comparative Tumor Biology group leaded by Prof. Kurzik-Dumke (2006 – 2011). In April 2011, he defended his PhD thesis: “Identification and characterization of the regulatory elements and factors of the human tumor suppressor gene tumorous imaginal discs (htid)”. Afterwards, he moved back to Poland, and since October 2011 he is working as a post-doc in the Institute of Hematology in Warsaw, in Prof. Juszczynski’s Lab. His scientific interests are genetic and epigenetic mechanisms underlying pathogenesis of cancer. He likes music, photography, cooking and sailing.

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Projekt realizowany w ramach programu TEAM Fundacji na rzecz Nauki Polskiej,
współfinansowany przez Unię Europejską z Europejskiego Funduszu Rozwoju Regionalnego